腦小膠質(zhì)細胞*來(lái)源于卵黃囊巨噬細胞；因此，在穩定狀態(tài)下，它們的功能可以直接歸因于這個(gè)譜系。出生后，小膠質(zhì)細胞數量的大量擴增*是通過(guò) M-CSF 和 CX3CR1 配體 IL-34 的原位增殖驅動(dòng)的，而無(wú)需單核細胞輸入 [1-4]。常駐小膠質(zhì)細胞在調節突觸發(fā)育方面具有關(guān)鍵的穩態(tài)功能。與胚胎一樣，小膠質(zhì)細胞在出生后保留其改變神經(jīng)元回路的能力，除了吞噬凋亡神經(jīng)元 [5] 外，它們通過(guò)吞噬神經(jīng)元突觸對突觸修剪至關(guān)重要 - 這些活動(dòng)對于大腦健康發(fā)育是必需的.重要的是，小膠質(zhì)細胞通過(guò)小膠質(zhì)細胞過(guò)程的擴展與突觸前和突觸后部位的神經(jīng)元動(dòng)態(tài)相互作用，其中長(cháng)時(shí)間接觸會(huì )導致神經(jīng)元消除[6]。 CX3CR1 的表達對于控制小膠質(zhì)細胞數量、突觸修剪和功能性大腦連接至關(guān)重要，這由 Cx3cr1 缺陷小鼠研究確定 [7]。
如何研究腦小膠質(zhì)細胞的功能？一個(gè)強有力的工具就是清除腦小膠質(zhì)巨噬細胞。靶點(diǎn)科技庫存大量LIPOSOMA的ClodronateLiposomes氯膦酸二鈉脂質(zhì)體。作為授權的中國Exclusive Distributor，無(wú)論從產(chǎn)品質(zhì)量還是技術(shù)支持，都能給予從理論到實(shí)踐的賦能。
參考文獻
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4. Ajami B, Bennett J, Krieger C, Tetzlaff W, Rossi F. Local self-renewal can sustain CNS microglia maintenance and function throughout adult life. Nat Neurosci. 2007;10:1538-43
5. Paolicelli R, Bolasco G, Pagani F, Maggi L, Scianni M, Panzanelli P, et al. Synaptic pruning by microglia is necessary for normal brain development. Science. 2011;333:1456-8
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